The pairing of Sophora flavescens and Fructus Ligustri lucidi is taken from Shi Jinmo Medicine. The idea behind this pairing was\ninspired by the similarity in pharmacological effects of the two herbal drugs, both ofwhich are known to be effective in the treatment\nand protection against liver fibrosis. To quantitatively study the extent of the interaction between these drugs and the effect of pairing\non the treatment of liver fibrosis, an animal model of liver fibrosis mice was established by intraperitoneal injection of low-dose\ncarbon tetrachloride.The drugs were then administered individually, or in predefined compatibility ratio pairs, by gavage, and the\neffects on indexes of liver fibrosis were observed.The multisynthetic index method was adopted using Matlab software in order to\nconstruct a three-dimensional response surface map of the integration effect and conduct interaction analysis of Sophora flavescens\nand Fructus Ligustri lucidi. The quadratic surface fitting pattern was designed by quadratic regression to determine the optimal\nrange of each drug.The obtained results show that when the compatibility ratio of Sophora flavescens-Fructus Ligustri lucidi drug\npairs is less than or equal to 1:1, their therapeutic effect is enhanced by synergy (interaction value ranging between -0.2 and -1).\nOverall, the synergy of the high-dose drug pairs is stronger than that of the low-dose drug pairs. The optimal dose ranges are 6 to 12\ng and 8 to 17 g for Sophora flavescens and Fructus Ligustri lucidi, respectively.
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